Twenty-five states had suicide rates that increasedmore than 30 percent, and the highest increase was seen in North Dakota at 57.6 percent.
Researchers say the nation's suicide rate is lowest in Washington D.C. and highest in Montana.
The rate of suicides in Maryland grew by 8.5 percent, well below the national increase from 1999-2016, according to the CDC.
There are many avenues for treatment, but experts say getting the right help begins with simply asking someone if they are having suicidal thoughts. CNN confirmed the death, calling it a suicide.
In exactly half of US states, the suicide rate increased more than 30 percent. "We don't really understand why there's such an increase", CBS News chief medical correspondent Dr. Jon LaPook said on "CBS This Morning".
The report said people without known mental health problems were more likely to die by firearms than those with known mental health problems.
There are many risk factors and warning signs. The ADAMHS Board operates the county's 24/7 suicide prevention crisis hotline at 216-623-6888.
Additionally, the report looked at the rates of emergency department visits for nonfatal self-harm, a major risk factor for suicide, which rose by 42 percent from 2001 to 2016.
The CDC report cites several different approaches, such as working to stabilize housing and teaching coping and problem-solving skills early in life.
"The mental health system, in a lot of ways, can feel like the power has been taken away, so one of those values in peer support is instead of a power imbalance, you're talking to someone who is going to be there with you and not tell you how to live your life but to explore options", Stohlmann-Rainey said.
"One of the things we keep coming back to when these surprising events happen is you never know what is in somebody's head", he said.
So, in order to get to treatment, you have to, A, increase the mental health resources upstream as far as possible, and, B, you have to destigmatize seeking treatment and receiving treatment.