Forward Anthony Martial could return at Old Trafford after missing two matches.
After Liverpool had a host of second half penalty appeals waved away by referee Craig Pawson, Aldridge has suggested his former club need to become more streetwise to match their rivals competing in the Premier League's top five.
"It's been a very good couple of weeks for Manchester United". With Mourinho at the helm, it is possible that United's struggles could be over. He has been there as an underdog with Porto and Inter Milan and won the competition with both.
United will be full of confidence after the weekend's brilliant result.
In fact, United have beaten every team below them at least once this season - from Spurs in third to bottom-placed West Brom - and have a (slim) chance to beat leaders Manchester City, as well as Arsenal for a second time, before the season is out.
The hard-won, but fragile optimism can easily be punctured.
Sevilla made it out of Group E in second place, finishing behind a Liverpool side that went unbeaten. Furthermore, Sevilla is not easy opponent as they are strong in attack. Manchester City might already have the League Cup, but they're out of the FA Cup.
"The most important thing is sticking together as a squad".
United have been incredible over the past few weeks.
On Saturday against Liverpool, it was impressive.
Mourinho's team drew 0-0 in Spain last month but have since beaten Chelsea and Liverpool at Old Trafford. He started, he had a good match and I'm not just speaking about scoring goals because, for me, the analysis of a performance is much more than analysing the number of goals or assists.
Sevilla looked to better team in the first leg and should certainly not be underestimated. He is starting to adapt to how Mourinho wants him to play.
Frank de Boer said that "it's a pity" Rashford plays under Mourinho, as his game time has been restricted under the Portuguese. "In time he will prove to be a top signing for United".
As things stand after a tiresome affair in the first leg, it's 0-0, with no away goal for United in Spain, and Sevilla failing to capitalise on their home advantage.
They have also come from behind in two of their previous three games, showing that this team has a fight some feared it was lacking.