Meanwhile, hundreds of scientists took to the streets of Boston urging Trump to recognize climate change and tackle environmental issues.
Two people at the Los Angeles rally outside city hall interviewed on MSNBC said they came because they find Trump purposely divisive and untruthful.
Where Will Your 'Not My Presidents Day' Rally Be Held?
"This march isn't about a specific policy or specific thing that Donald Trump has done".
In Georgia - a state known for its peaches - protesters gathered for what they called the ImPEACH NOW! rally.
They will gather on what they're calling "Not My President's Day" and march from The Arts Center Marta Station and ending at Lenox Mall.
Presidents' Day commemorates the birth of first U.S. President George Washington, but is often observed to honor all past American commanders in-chief.
Chicago police reported no arrests in the protest, the latest in a series since Trump's January 20 inauguration.
A small but unruly group of protesters faced off with police in downtown Portland, Oregon.
Hundreds of Trump opponents and supporters turned out in Rapid City, South Dakota.
"I think that Trump is a clear and present danger to our republic and to our democratic institutions and to numerous groups of people, both in the country and around the world", said Protester, Ross Allued. Some protesters waved American flags, while others held signs saying "No Muslim Ban".