Already we have seen the Trump Administration warming his seat by threatening to lift the USA sanctions that were a response to Russian aggression against our allies and our own national security.
President Donald Trump will partake in Tillerson's swearing in ceremony at 6:45 p.m. Wednesday evening.
Tillerson was sworn in by Vice President Pence, as his wife held the Bible.
The 64-year-old former chairman and chief executive of Exxon Mobil was confirmed by the Senate in a 56-43 vote.
While the upper chamber was busy elevating a man to whom Putin personally awarded Russia's Order of Friendship to be the new driving force behind American diplomatic policy, hey, what was the House up to?
Additionally, Mr Trump has said he was open to lifting sanctions imposed on Russian Federation in 2014 for their illegal annexation of Ukraine's Crimea peninsula - which could directly benefit ExxonMobil, as Mr Tillerson brokered $500bn (£409bn) energy partnership with the country.
If confirmed, however, one of Mr. Tillerson's first priorities will be implementing parts of Mr. Trump's refugee and visa ban, one that many lower-level State Department officials and Foreign Service officers are reportedly condemning as misguided.
For his part, Wisner says he believes Tillerson will be a solid secretary of state due to his global negotiating experience as an worldwide oilman, someone who will serve as "a force for good sense, good judgement and mature reflection" in the administration. There's rarely been conflict in the world like we see today.
But Democrats lack the numbers in the Senate to block Tillerson from becoming the nation's chief diplomat.
"You understand the job of our diplomats, and the mission of the State Department, is to serve the interests of the United States of America to make our nation safer, our country more prosperous, and all our people much more secure", Trump said.
Sen. Diane Feinstein, a California Democrat, said she voted against Tillerson because he claimed not to know about Exxon's history of lobbying Congress in opposition to sanctions on Iran and Russian Federation.
The president used his personal Twitter account to say around 6:30 a.m. Thursday that Iran has been "formally PUT ON NOTICE for firing a ballistic missile", apparently using all capital letters to add weight to his words.
Tillerson originally supported Jeb Bush for President.
The changing of the guard from former Secretary of State John Kerry - who attended worldwide climate talks years ago as the sole member of Congress - to Tillerson, an icon of the oil and gas industry, has alarmed environmentalists. Today, other agencies, such as the Commerce Department have taken on some of that role, but the State Department under Tillerson could provide more aggressive assistance to American economic interests overseas.
Tillerson's confirmation was more contentious than those of his predecessors.
The vote was the "biggest blow yet" in an effort to "demonize the oil and gas industry", the group said in a statement.
Tillerson, however, was deemed highly qualified for the position by the Republicans as they rejected the Democrat's concerns.
Talking on MSNBC yesterday, Sen. "Hi, I'm the new guy". The answer is known to every school child, Heinrich said.
At Exxon, Tillerson was the ultimate insider.
Tillerson's record on climate change also came under scrutiny. Chris Murphy (D-Conn.). Each of us is entitled to the expression of our political beliefs.
The Senate is set Monday to vote on moving forward on President Trump's nomination of Rex Tillerson to lead the State Department.