Sky Sports noted he made more "high intensity sprints" than any other City player has all season with 91.
The match ended in a 2-2 draw but arguably the course of the match, and result, could have been very different in a game between two sides vying for the title.
Both teams tried to press with ruthless energy and perhaps it was a surprise to some that City were far more effective, though this has always been a Guardiola tactic. "It's more important that we can show ourselves, rather than show Manchester City".
Tottenham Hotspur: Lloris 3, Walker 6, Dier 5, Alderweireld 6, Wimmer 5, Rose 6, Wanyama 7, Dembele 6, Eriksen 5, Alli 7, Kane 5.
Just a well-timed deal with from behind by Toby Alderweireld stopped Pablo Zabaleta capturing from 12 lawns out prior to the protector terminated directly vast from an edge after Lloris tipped a shot from David Silva behind.
Eric Dier was dispossessed by Sergio Agüero as he attempted to dribble out of defence, but De Bruyne pulled his shot from the right just past the Spurs goal line.
But with Spurs three places above City in second place, Pochettino says he feels none of the trepidation he felt when taking his former club Espanyol to face Guardiola's all-conquering Barcelona. However, it's the few chances that City allow which make the difference on the score sheet.
Leroy Sane in action with Hugo Lloris before scoring Manchester City's first goal. Soon after, Sergio Aguero almost scored twice inside a minute, the first a brilliant header that forced a flying catch by Lloris. Neither switch granted Spurs immunity to through-balls, though, and City should have had a penalty when Sterling ran through and got pushed by Walker. It was another blunder by the keeper, who handed Manchester City a two-goal cushion.
The agony multiplied for Lloris.
Minutes later Lloris spilled Raheem Sterling's low cross to De Bruyne who doubled the lead.
Kyle Walker of Tottenham.
But Spurs ensured there was a share of the points by showing the fortitude and resilience to come from behind, with goals from Dele Alli and Son.
City could have wrapped the game up when Sterling went clean through on goal, but under pressure from Walker - who seemed to give the City winger a sneaky push - he prodded straight at Lloris. Guardiola was understandably furious.
Guardiola sent on new signing Gabriel Jesus for his debut in a late attempt to salvage the win. Then, he leaped like a salmon towards a cross and nearly scored an immaculate header, but his effort was inches above the bar. Mancini and Pellegrini faced sides that sat deep, conceding possession to the home team and trying to battle for whatever they could get on the break.