"We had a absolutely disgusting week and what is worse is out of two good performances we got zero points", Wenger added.
A win for Chelsea combined with a defeat for Arsenal would leave its gap at nine points, while a City defeat would mean the Manchester club falling 10 points adrift.
The question Arsenal have failed to answer on so many occasions since "The Invincibles" went 38 games unbeaten to win their last title in 2003-04 is - could they stand it when the heat was on, when the physical and mental pressures were at their height?
The victory over Arsenal keeps City seven points behind leaders Chelsea, who have won their last 11 Premier League games with City taking just 15 fewer points during that time.
Inevitably, frustrated Arsenal fans were quick to point fingers after such a lacklustre display.
"I'm disappointed and frustrated", he said.
Wenger's side have only lost to title rivals Liverpool and Merseyside outfit Everton in the Premier League in the 2016-17 season so far.
The result lifts City up to second in the Premier League, while Arsenal drop to fourth.
Thibaut Courtois has admitted Chelsea will miss Diego Costa
But it was Sane and Sterling who provided the second-half goals as City roared back to secure a victory which has been a long-time coming.
City could have had more as a shellshocked Arsenal were cut apart, De Bruyne hitting the post off a Navas cross, whilst their hosts offered little sense they would mount a stirring fightback.
"What you want of a top level game is that it responds to the expectation, quality-wise". They did beat Watford on Wednesday night but had lost back-to-back league games prior to that.
The City defence was all at sea and manager Pep Guardiola had his head in his hands.
Manchester City's Nigerian forward, Kelechi Iheanacho and his club teammates committed funds to refurbish the Child and Adolescent Mental Health ward of the Royal Manchester Children's Hospital on Friday, Completesportsnigeria.com reports..
"Arsenal have not lost to City in any competition for almost three years - and I believe they can extend that record on Sunday". Signed from Everton for £47.5 million (S$85.8 million), the 22-year-old became the most expensive defender in British football history.
In fact, you would imagine only Sterling, Sane and De Bruyne of today's starting XI, if not the whole squad, will still be around by the time Guardiola has fully got to grips with City.
Asked by his former player Thierry Henry about the current run of form his team is on, Guardiola said that he always knew he would need to face a hard stretch at some point, as that is merely part of a manager's career. "If they could make the right decision, it would be even better".